In most cases, your SecuROM™ protected application should run just fine, as long as you do not change too many hardware components.
SecuROM™ checks offline on every start of the application if the hardware has changed between the stored hardware ID in the SecuROM™ User Data and a recalculation of the current hardware.
There is flexibility (set by the publisher, but defaults to 60%) of allowed hardware changes before a new activation is required.
A re-activation is necessary, after re-formatting a HDD and new Windows setup, as well as after creating a new Windows User account. For software changes, the SecuROM™ User Data are stored on two positions (Windows registry and the user APPDATA folder).
Note: The Product Activation servers differentiate between activations on same and different PCs.
We highly suggest revoking your license before changing the hardware and to re-activate your application afterwards.